Sildenafil inhibits phosphodiesterase type 5 in human clitoral corpus cavernosum smooth muscle.

@article{Park1998SildenafilIP,
  title={Sildenafil inhibits phosphodiesterase type 5 in human clitoral corpus cavernosum smooth muscle.},
  author={Kae Chang Park and R B Moreland and Irwin S. Goldstein and Anthony J Atala and Abdulmaged M Traish},
  journal={Biochemical and biophysical research communications},
  year={1998},
  volume={249 3},
  pages={612-7}
}
Phosphodiesterases play an important physiological role by regulating the intracellular levels of cyclic nucleotides. In this study, we investigated the kinetic parameters of inhibition of phosphodiesterase (PDE) type 5 (EC 3.1.4.35, 3',5'-cyclic GMP phosphodiesterase) by a novel, high-affinity, selective PDE type 5 inhibitor, sildenafil, in intact cells and in soluble extracts of human clitoral corpus cavernosum smooth muscle cells. Sildenafil inhibited cGMP hydrolysis in the crude extract (Ki… CONTINUE READING

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