Sildenafil inhibits gastroduodenal motility.


BACKGROUND Sildenafil shows an intense and prolonged inhibitory effect on the smooth muscle cells of corpus cavernosum arterioles by blocking phosphodiesterase-type 5, which inactivates the nitric oxide-stimulated cyclic guanosine monophosphate. AIM To investigate whether this inhibitory effect is also displayed on the musculature of the gastroduodenal… (More)


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