Sildenafil does not improve cardiomyopathy in Duchenne/Becker muscular dystrophy.

@article{Leung2014SildenafilDN,
  title={Sildenafil does not improve cardiomyopathy in Duchenne/Becker muscular dystrophy.},
  author={Doris G Leung and Daniel A. Herzka and W. R. Thompson and Bing He and Genila M Bibat and Gihan Tennekoon and Stuart D. Russell and Karl H. Schuleri and Albert C. Lardo and David A. Kass and Richard E. Thompson and Daniel P Judge and Kathryn R. Wagner},
  journal={Annals of neurology},
  year={2014},
  volume={76 4},
  pages={541-9}
}
OBJECTIVE Duchenne and Becker muscular dystrophies (DBMD) are allelic disorders caused by mutations in dystrophin. Adults with DBMD develop life-threatening cardiomyopathy. Inhibition of phosphodiesterase 5 (PDE5) improves cardiac function in mouse models of DBMD. To determine whether the PDE5-inhibitor sildenafil benefits human dystrophinopathy, we conducted a randomized, double-blind, placebo-controlled trial (ClinicalTrials.gov, number NCT01168908). METHODS Adults with DBMD and… CONTINUE READING