Sildenafil citrate protects against gastric mucosal damage induced by indomethacin in rats.

@article{Moustafa2013SildenafilCP,
  title={Sildenafil citrate protects against gastric mucosal damage induced by indomethacin in rats.},
  author={Yasser M. Moustafa and D M Khoder and EL-SAYED E. EL-AWADY and Sawsan Abo-Bakr Zaitone},
  journal={European review for medical and pharmacological sciences},
  year={2013},
  volume={17 2},
  pages={179-88}
}
BACKGROUND AND OBJECTIVES   The present study was conducted to investigate the possible gastroprotective effect of sildenafil citrate, a selective inhibitor of cyclic guanosine monophosphate-specific phosphodiesterase, against indomethacin-induced gastric damage in rats. Further, the study was extended to investigate some possible mechanisms underlying this effect. MATERIALS AND METHODS Forty rats were assigned to vehicle (saline), control (indomethacin, 30 mg/kg, p.o.), ranitidine (50 mg/kg… CONTINUE READING

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