Sildenafil citrate alleviates pulmonary hypertension after hypoxia and reoxygenation with cardiopulmonary bypass.

Abstract

BACKGROUND Sudden reoxygenation of hypoxic neonates undergoing cardiac operation exacerbates the systemic inflammatory response to cardiopulmonary bypass secondary to reoxygenation injury, worsening cardiopulmonary dysfunction. Reports suggest sildenafil decreases pulmonary hypertension and may affect myocardial function. Sildenafil's efficacy for treating… (More)

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@article{Lyons2004SildenafilCA, title={Sildenafil citrate alleviates pulmonary hypertension after hypoxia and reoxygenation with cardiopulmonary bypass.}, author={Jefferson M Lyons and Jodie Y Duffy and Connie J Wagner and Jeffrey M Pearl}, journal={Journal of the American College of Surgeons}, year={2004}, volume={199 4}, pages={607-14} }