Sildenafil-associated hepatoxicity: a review of the literature.


Sildenafil citrate (Viagra®) is a vasoactive agent available worldwide since 1998 for the treatment of male erectile dysfunction. It is a selective phosphodiesterase type 5-enzyme inhibitor able to potentiate the downstream effects of nitric oxide on smooth muscle relaxation and vasodilation through its effects on the cyclic guanosine monophosphate (c-GMP… (More)


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@article{Graziano2017SildenafilassociatedHA, title={Sildenafil-associated hepatoxicity: a review of the literature.}, author={S. Graziano and Angelo Montana and Simona Zaami and Maria Concetta Rotolo and Adele Minutillo and Francesco Paolo Busard{\`o} and Eugene Marinelli}, journal={European review for medical and pharmacological sciences}, year={2017}, volume={21 1 Suppl}, pages={17-22} }