Sildenafil and vardenafil, types 5 and 6 phosphodiesterase inhibitors, induce caspase-dependent apoptosis of B-chronic lymphocytic leukemia cells.

@article{Sarfati2003SildenafilAV,
  title={Sildenafil and vardenafil, types 5 and 6 phosphodiesterase inhibitors, induce caspase-dependent apoptosis of B-chronic lymphocytic leukemia cells.},
  author={Marika Sarfati and V{\'e}ronique Mat{\'e}o and Sylvie Baudet and M. Luz Rubio and Christine Fernandez and Frederic Davi and J. P. Binet and Jozo Deli{\'c} and H{\'e}l{\`e}ne Merle-B{\'e}ral},
  journal={Blood},
  year={2003},
  volume={101 1},
  pages={265-9}
}
Type 4 phosphodiesterase (PDE4) inhibitors reportedly induce apoptosis in chronic lymphocytic leukemia (CLL) cells. Following clinical improvement of one previously untreated CLL patient with sildenafil therapy, we evaluated the in vitro induction of apoptosis in CLL cells by 4 PDE5/6 inhibitors, including sildenafil, vardenafil, zaprinast, and methoxyquinazoline (MQZ). After 24 hours of culture, the various PDE inhibitors differed in their ability to induce apoptosis, with zaprinast displaying… CONTINUE READING
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PK11195, a mitochondrial benzodiazepine receptor antagonist, as a new therapy for CLL: B-cell lymphoproliferative disorders

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