Sildenafil Increases Muscle Protein Synthesis and Reduces Muscle Fatigue

@article{SheffieldMoore2013SildenafilIM,
  title={Sildenafil Increases Muscle Protein Synthesis and Reduces Muscle Fatigue},
  author={M. Sheffield-Moore and J. Wiktorowicz and K. Soman and C. Danesi and M. Kinsky and E. L. Dillon and K. Randolph and Shannon L. Casperson and D. Gore and A. Horstman and J. Lynch and B. M. Doucet and Joni A. Mettler and J. Ryder and L. Ploutz-Snyder and Jean W Hsu and F. Jahoor and K. Jennings and G. R. White and S. McCammon and W. Durham},
  journal={Clinical and Translational Science},
  year={2013},
  volume={6}
}
Reductions in skeletal muscle function occur during the course of healthy aging as well as with bed rest or diverse diseases such as cancer, muscular dystrophy, and heart failure. However, there are no accepted pharmacologic therapies to improve impaired skeletal muscle function. Nitric oxide may influence skeletal muscle function through effects on excitation‐contraction coupling, myofibrillar function, perfusion, and metabolism. Here we show that augmentation of nitric oxide‐cyclic guanosine… Expand
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