Sildenafil Improves Exercise Hemodynamics and Oxygen Uptake in Patients With Systolic Heart Failure

@article{Lewis2007SildenafilIE,
  title={Sildenafil Improves Exercise Hemodynamics and Oxygen Uptake in Patients With Systolic Heart Failure},
  author={G. Lewis and J. Lachmann and Janice M. Camuso and J. Lepore and J. Shin and M. Martinovic and D. Systrom and K. Bloch and M. Semigran},
  journal={Circulation},
  year={2007},
  volume={115},
  pages={59-66}
}
  • G. Lewis, J. Lachmann, +6 authors M. Semigran
  • Published 2007
  • Medicine
  • Circulation
  • Background— Heart failure (HF) is frequently associated with dysregulation of nitric oxide–mediated pulmonary vascular tone. Sildenafil, a type 5 phosphodiesterase inhibitor, lowers pulmonary vascular resistance in pulmonary hypertension by augmenting intracellular levels of the nitric oxide second messenger, cyclic GMP. We tested the hypothesis that a single oral dose of sildenafil (50 mg) would improve exercise capacity and exercise hemodynamics in patients with chronic systolic HF through… CONTINUE READING

    Paper Mentions

    OBSERVATIONAL CLINICAL TRIAL
    This study will better understand the post-capillary pulmonary hypertension in heart failure, to determine its prognostic role and to consider specific treatment of different forms of… Expand
    ConditionsHeart Failure, Post-capillary Pulmonary Hypertension
    Long-term use of sildenafil in the therapeutic management of heart failure.
    • 327
    • Open Access

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