Sildenafil Ameliorates Gentamicin-Induced Nephrotoxicity in Rats: Role of iNOS and eNOS

@inproceedings{Morsy2014SildenafilAG,
  title={Sildenafil Ameliorates Gentamicin-Induced Nephrotoxicity in Rats: Role of iNOS and eNOS},
  author={Mohamed Abdelhamed Morsy and Salwa Ah Ibrahim and Entesar Farghaly Amin and Maha Yehia Kamel and Rehab Ahmed Rifaai and Magdy K. Abdel-Aal Hassan},
  booktitle={Journal of toxicology},
  year={2014}
}
Gentamicin, an aminoglycoside antibiotic, is used for the treatment of serious Gram-negative infections. However, its usefulness is limited by its nephrotoxicity. Sildenafil, a selective phosphodiesterase-5 inhibitor, was reported to prevent or decrease tissue injury. The aim of this study is to evaluate the potential protective effects of sildenafil on gentamicin-induced nephrotoxicity in rats. Male Wistar rats were injected with gentamicin (100 mg/kg/day, i.p.) for 6 days with and without… CONTINUE READING