Sildenafil: clinical toxicology profile.

  title={Sildenafil: clinical toxicology profile.},
  author={Edward P Krenzelok},
  journal={Journal of toxicology. Clinical toxicology},
  volume={38 6},
BACKGROUND Sildenafil is indicated for the treatment of male erectile dysfunction. It has been used successfully in males to remediate problems associated with impaired neural and/or hemodynamic response to sexual stimulation. Sildenafil is a cyclic guanosine-specific phosphodiesterase type 5 inhibitor that prevents the metabolism of cyclic guanosine which produces arterial smooth muscle relaxation within the corpora cavernosa of the penis and ultimately enhances penile tumescence. Inherent to… CONTINUE READING
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