Sildenafil, a phosphodiesterase-5 inhibitor, enhances the antinociceptive effect of morphine.

@article{Jain2003SildenafilAP,
  title={Sildenafil, a phosphodiesterase-5 inhibitor, enhances the antinociceptive effect of morphine.},
  author={Naveen K. Jain and Chandrashekhar S. Patil and Amarjit Singh and Shrinivas Krishnarao Kulkarni},
  journal={Pharmacology},
  year={2003},
  volume={67 3},
  pages={150-6}
}
Various evidence has demonstrated a role of the nitric oxide (NO)/cGMP signaling pathway in the processing of nociception. The exact role of phosphodiesterase-5 (PDE-5) via the NO/cGMP pathway is not fully understood in pain response. The aim of the present study was to investigate the possible peripheral interaction between a PDE-5 inhibitor (sildenafil) and morphine. Carrageenan-induced hyperalgesia in rats and the acetic-acid-induced writhing test in mice were used as animal models. Local… CONTINUE READING
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