Signs of impaired immunoregulation and enhanced effector T-cell responses in the primary antiphospholipid syndrome.


INTRODUCTION We investigated whether primary antiphospholipid syndrome (PAPS) is characterized by a deficiency in immunoregulatory pathways, a phenomenon recently implicated in the pathogenesis of autoimmune diseases. METHODS Serum levels of immunoregulatory (e.g., IL-10 and TGF-β1) and proinflammatory (e.g., IL-17A) cytokines were measured in PAPS… (More)
DOI: 10.1177/0961203315618267


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