Signs and symptoms to determine if a patient presenting in primary care or hospital outpatient settings has COVID‐19 disease

  title={Signs and symptoms to determine if a patient presenting in primary care or hospital outpatient settings has COVID‐19 disease},
  author={Thomas Struyf and Jonathan J. Deeks and Jacqueline Dinnes and Yemisi Takwoingi and Clare F Davenport and Mariska M. G. Leeflang and Ren{\'e} Spijker and Lotty Hooft and Devy M. Emperador and Sabine Dittrich and Julie Domen and Sebastiaan R A Horn and Ann Van den Bruel},
  journal={The Cochrane Database of Systematic Reviews},
Abstract Background Some people with SARS‐CoV‐2 infection remain asymptomatic, whilst in others the infection can cause mild to moderate COVID‐19 disease and COVID‐19 pneumonia, leading some patients to require intensive care support and, in some cases, to death, especially in older adults. Symptoms such as fever or cough, and signs such as oxygen saturation or lung auscultation findings, are the first and most readily available diagnostic information. Such information could be used to either… 

Signs and symptoms to determine if a patient presenting in primary care or hospital outpatient settings has COVID‐19

To assess the diagnostic accuracy of signs and symptoms to determine if a person presenting in primary care or to hospital outpatient settings, such as the emergency department or dedicated COVID-19 clinics, has CO VID-19, 44 studies are identified.

Signs and symptoms to determine if a patient presenting in primary care or hospital outpatient settings has COVID‐19

The applicability of the results of this review iteration improved in comparison with the previous reviews, and more studies of people presenting to ambulatory settings, which is where the majority of assessments for COVID‐19 take place.

Age and clinical signs as predictors of COVID-19 symptoms and cycle threshold value

Compared with asymptomatic patients, symptomatic patients with COVID-19 are most likely to be febrile, tachycardic, hypoxic and having higher viral load.

The Multifacets of COVID-19 in Adult Patients: A Concise Clinical Review on Pulmonary and Extrapulmonary Manifestations for Healthcare Physicians

There is an urgent need to rapidly scale up the diagnostic capacity to detect COVID-19 and its complications and a concise review shows that there is a wide range of symptoms that can be presented by CO VID-19 patients.


The patient was diagnosed to have multisystem inflammatory syndrome in children (MIS-C) according to the US Centers for Disease Control and Prevention definition criteria with the presence of fever, elevated inflammatory markers, multis System involvement (cardiovascular, gastrointestinal and dermatologic), history of COVID-19 exposure and positive serology.

Prevalence of COVID-19 Mimics in the Emergency Department

Several potentially fatal diseases remain masked among the wave of CO VID-19 mimics and it is imperative that a thorough differential diagnostic panel be considered prior to the rendering of a COVID-19 diagnosis.

Thoracic imaging tests for the diagnosis of COVID‐19

There was no statistical evidence indicating that reference standard conduct and definition for index test positivity were sources of heterogeneity for CT studies, and the uncertainty of accuracy estimates using 95% confidence intervals (CIs) was low.

Symptoms at presentation for patients admitted to hospital with Covid-19: results from the ISARIC prospective multinational observational study

Older adults and children admitted to hospital with Covid-19 are less likely to present with typical symptoms of cough, fever and shortness of breath, and regression models showed significant differences in symptoms with age, and considerable heterogeneity between countries.

Early Symptoms of Patients With COVID-19 in Family Medicine Centers in South India: A Retrospective Study

The results of the study reiterates the role of social distancing, self-isolation, proper masking, and greater vaccination coverage as significant public health interventions.

[COVID suspected patients in Primary Care in Madrid at the beginning of first wave: Clinical characteristics and healthcare assistance.]

Age and male gender were related to pneumonia onset in PC and health care provision by PC, and professional sick leaves could affect the quality of care.



Covid-19 Testing, Hospital Admission, and Intensive Care Among 2,026,227 United States Veterans Aged 54–75 Years

Black race was strongly associated with Covid-19+, but not with hospitalization or intensive care, and risk of hospitalization and intensive care may be better characterized by laboratory measures and vital signs than by comorbid conditions or prior medication exposure.

Diagnosis of SARS-CoV-2 infection and COVID-19: accuracy of signs and symptoms; molecular, antigen, and antibody tests; and routine laboratory markers

This is a protocol for a Cochrane Review (diagnostic) to assess the diagnostic accuracy of laboratory real-time polymerase chain reaction (RT-PCR) and other laboratory molecular tests to determine if a person presenting in the community or in secondary care has SARS-CoV-2 infection.

Imaging tests for the diagnosis of COVID-19

A protocol for a Cochrane Review to determine the diagnostic accuracy of chest imaging in the evaluation of people suspected to have COVID-19 and the rate of alternative diagnoses identified by chest imaging.

Distinguishing COVID-19 From Influenza Pneumonia in the Early Stage Through CT Imaging and Clinical Features

COVID-19 can be distinguished from influenza pneumonia based on CT imaging and clinical features, with the highest AUC of 0.991, of which crazy-paving pattern and WBC count play most important role in the differential diagnosis.

Clinical Features and Chest CT Manifestations of Coronavirus Disease 2019 (COVID-19) in a Single-Center Study in Shanghai, China.

At the point during the COVID-19 outbreak when this study was performed, imaging patterns of multifocal, peripheral, pure G GO, mixed GGO, or consolidation with slight predominance in the lower lung and findings of more extensive GGO than consolidation on chest CT scans obtained during the first week of illness were considered findings highly suspicious of CO VID-19.

A novel high specificity COVID-19 screening method based on simple blood exams and artificial intelligence

An artificial intelligence classification framework, ER-CoV, is built aiming at determining which patients were more likely to be negative for SARS- CoV-2 when visiting an ER and that were categorized as a suspect case by medical professionals.

COVID-19 early warning score: a multi-parameter screening tool to identify highly suspected patients

The new developed COVID-19 EWS was a considerable tool for early and relatively accurately warning of SARS-CoV-2 infected patients and indicated that both of the diagnostic model had good discrimination capacity.

Prevalence and clinical features of 2019 novel coronavirus disease (COVID-19) in the Fever Clinic of a teaching hospital in Beijing: a single-center, retrospective study

The prevalence of COVID-19 in all pneumonia patients during the study period was 6.14%, Epidemiological evidence was important for prompt case finding, and lower blood WBC and neutrophil counts may be useful for differentiation from pneumonia of other etiologies.

A novel specific artificial intelligence-based method to identify COVID-19 cases using simple blood exams

An artificial intelligence classification framework aimed at determining if suspect patients arriving in ER were likely to be negative for SARS-CoV-2, that is, to predict if that suspect patient is negative for COVID-19 is developed, with the goal of providing an effective low-cost system to triage suspect patients in ERs.

A comparative study on the clinical features of COVID-19 pneumonia to other pneumonias

  • Dahai ZhaoFei-Rong Yao R. Gao
  • Medicine
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2020
The 2019-nCoV infection caused similar onsets to other pneumonias, and liver function damage is more frequent in NCOVID-19 than NON-NCOVID-19 patients, and CT scan may be a reliable test for screening NCO VID-19 cases.