Signs and symptoms of reflex sympathetic dystrophy: prospective study of 829 patients

@article{Veldman1993SignsAS,
  title={Signs and symptoms of reflex sympathetic dystrophy: prospective study of 829 patients},
  author={P H Veldman and H. M Reynen and Ivo E. Arntz and R. Jan A. Goris},
  journal={The Lancet},
  year={1993},
  volume={342},
  pages={1012-1016}
}
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1,145 Citations
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1,145 Citations

Clinical aspects of reflex sympathetic dystrophy

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Reflex sympathetic dystrophy indicates the syndrome of a painful, swollen, discoloured, abnormally sensitive, and useless extremity, usually developing after trauma, and first described as a…

Reflex Sympathetic Dystrophy Following Knee Surgery

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D Disorders considered to be RSD and causalgia are now classified under the term complex regional pain syndrome (CRPS) and are based entirely on clinical criteria.

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The results suggest no significant relationship between the severity of injury and risk of RSD occurrence, although the mean injury severity score was higher in patients with RSD than in those without RSD in this study population.

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TLDR
Although the primary etiology for CRPS is not clearly understood, key progress has been made in terms of establishing a psychological as well as therapeutic treatment plan once the diagnosis has be made.

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TLDR
The management period is long and this causes higher therapeutic costs in addition to loss of productive effort, however, response to therapy is good and in approximately one third of the patients, RSD does not improve despite all therapeutic interventions.

Reflex sympathetic dystrophy: complex regional pain syndrome type I in children with mitochondrial disease and maternal inheritance

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In one tertiary-care paediatric genetics practice, children meeting the CRPS-I diagnostic criteria frequently had additional autonomic-related conditions secondary to maternally inherited mitochondrial disease, suggesting that mitochondrial DNA sequence variants can predispose children towards the development of CR PSI and other dysautonomias.

[Complex regional pain syndrome: epidemiology, pathophysiology, clinical manifestations, diagnostic tests and therapeutic proposals.].

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A literature review of several CRPS aspects, with emphasis in its causes, definition and taxonomy, pathophysiology, clinical characteristics, diagnostic tests and most recent therapies.
...

References

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TLDR
There is a consensus that the best results will be achieved if treatment is started early and adapted to the clinical stage of the disease, and proper management may result in the prevention of crippling sequelae.

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Conservative treatment with physical therapy, transcutaneous electrical nerve stimulation, psychological therapies including cognitive-behavioral management and relaxation training, and tricyclic anti-depressants was effective in improving the average scores for pain and function for forty patients.

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