Signs, symptoms, metastatic spread and metabolic behavior of neuroblastomas treated in Denmark during the period 1943-1980.

@article{Carlsen1987SignsSM,
  title={Signs, symptoms, metastatic spread and metabolic behavior of neuroblastomas treated in Denmark during the period 1943-1980.},
  author={Niels Lauritz Torp Carlsen and Henrik Schroeder and Ib Jarle Christensen and Peter Bro and Ulla Hesselbjerg and Klaus B. Jensen and Ole Henrik Nielsen},
  journal={Anticancer research},
  year={1987},
  volume={7 3 Pt B},
  pages={465-73}
}
The clinical manifestations of 253 neuroblastoma cases in childhood, treated in Denmark from 1943 to 1980, were reviewed. Most striking was the vagueness of symptoms in the majority of patients, only a few of whom exhibited the symptoms strongly suggestive of a neuroblastoma (i.e. the Horner syndrome, the watery diarrhoea syndrome, the dancing eye syndrome). The vagueness of the symptoms might have led to fatal procrastination of the diagnosis. The diagnostic delay has, however, no independent… CONTINUE READING