Significantly enhanced production of acarbose in fed-batch fermentation with the addition of S-adenosylmethionine.

@article{Sun2012SignificantlyEP,
  title={Significantly enhanced production of acarbose in fed-batch fermentation with the addition of S-adenosylmethionine.},
  author={L Sun and Ming-Gang Li and Yuan-shan Wang and Yuguo Zheng},
  journal={Journal of microbiology and biotechnology},
  year={2012},
  volume={22 6},
  pages={826-31}
}
Acarbose, a pseudo-oligosaccharide, is widely used clinically in therapies for non-insulin-dependent diabetes. In the present study, S-adenosylmethionine (SAM) was added to selected media in order to investigate its effect on acarbose fermentation by Actinoplanes utahensis ZJB- 08196. Acarbose titer was seen to increase markedly when concentrations of SAM were added over a period of time. The effects of glucose and maltose on the production of acarbose were investigated in both batch and fed… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 27 references

A new microtiter plate-based screening method for microorganisms producing alpha-amylase inhibitors

  • Feng, Z.-H, Y.-S. Wang, Y.-G. Zheng
  • Biotechnol. Bioprocess Eng
  • 2011
1 Excerpt

Optimization of media composition and culture conditions for acarbose production by Actinoplanes utahensis ZJB-08196

  • Wang, Y.-J, L.-L. Liu, Z.-H. Feng, Z.-Q. Liu, Y.-G. Zheng
  • World J. Microbiol. Biotechnol
  • 2011
3 Excerpts

Comprehensive effects of maltose concentration and medium osmotic pressure on acarbose in Actinoplanes sp

  • W. Jiang, Y. T. Sheng, Y. M. Cai, M. J. Guo, J. Chu
  • fermentation. Chin. J. Pharm
  • 2010
2 Excerpts

Comprehensive effects of maltose concentration and medium osmotic pressure on acarbose in Actinoplanes sp . fermentation

  • J. H. Huh, Y. Y. Yang, C. M. Kang, I. H. Lee
  • Chin . J . Pharm .
  • 2010

Similar Papers

Loading similar papers…