Significantly altered systemic exposure to atorvastatin acid following gastric bypass surgery in morbidly obese patients.

@article{Skottheim2009SignificantlyAS,
  title={Significantly altered systemic exposure to atorvastatin acid following gastric bypass surgery in morbidly obese patients.},
  author={Ine Blankenberg Skottheim and Kjartan Stormark and Hege Christensen and Gunn Signe Jakobsen and Joeran Hjelmesaeth and Trond Geir Jenssen and Jan Leon Egge Reubsaet and Rune Sandbu and Anders {\AA}sberg},
  journal={Clinical pharmacology and therapeutics},
  year={2009},
  volume={86 3},
  pages={311-8}
}
The impact of gastric bypass on atorvastatin pharmacokinetics was investigated in 12 morbidly obese patients being treated with 20-80 mg atorvastatin each morning. Eight-hour pharmacokinetic investigations were performed the day before the surgery and at a median of 5 weeks (range 3-6 weeks) after the surgery. Gastric bypass surgery produced a variable effect on individual systemic exposure to atorvastatin acid (area under the plasma concentration vs. time curve from 0 to 8 h postdose (AUC(0-8… CONTINUE READING