Significantly Higher Peripheral Insulin-Like Growth Factor-1 Levels in Patients With Major Depressive Disorder or Bipolar Disorder Than in Healthy Controls

@inproceedings{Tu2016SignificantlyHP,
  title={Significantly Higher Peripheral Insulin-Like Growth Factor-1 Levels in Patients With Major Depressive Disorder or Bipolar Disorder Than in Healthy Controls},
  author={Kun-Yu Tu and Ming-Kung Wu and Yen-Wen Chen and Pao-Yen Lin and Hung-Yu Wang and Ching-Kuan Wu and Ping-Tao Tseng},
  booktitle={Medicine},
  year={2016}
}
An increasing amount of research has focused on insulin-like growth factor-1 (IGF-1) because of multiple neurotrophic effects, including neurogenesis, remyelination, and synaptogenesis. In addition, IGF-1 can mediate an antidepressant effect in patients with major affective disorder, and its levels in the cerebrospinal fluid have been found to vary with antidepressant treatment. Furthermore, it has been proven to crossover the blood-brain barrier, with a reciprocal feedback loop being the… CONTINUE READING
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