Significant therapeutic response to cysteamine cream in a melasma patient resistant to Kligman's formula

@article{Kasraee2019SignificantTR,
  title={Significant therapeutic response to cysteamine cream in a melasma patient resistant to Kligman's formula},
  author={Behrooz Kasraee and Parvin Mansouri and Susan Farshi},
  journal={Journal of Cosmetic Dermatology},
  year={2019},
  volume={18},
  pages={293 - 295}
}
L‐Cysteamine is a biological antioxidant produced during the coenzyme A metabolism cycle and is naturally present in all mammalian cells. The efficacy of topical cysteamine for the treatment of melasma has been recently shown in two double‐blind, randomized, and placebo‐controlled clinical trials. Herein, we report a 44‐year‐old patient with melasma resistant to Kligman's formula (Pigmanorm cream), who was successfully treated with topical cysteamine as a new depigmenting agent. Skin… 
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References

SHOWING 1-10 OF 16 REFERENCES
Efficacy of cysteamine cream in the treatment of epidermal melasma, evaluating by Dermacatch as a new measurement method: a randomized double blind placebo controlled study
TLDR
Cysteamine cream showed significant efficacy in decreasing melanin content of the lesions, as established by Dermacatch® as a new measuring method.
Comparison between Intralesional Triamcinolone and Kligman's Formula in Treatment of Melasma.
TLDR
In comparison to topical treatments, triamcinolone microinjection is a new, safe and strong therapeutic method for treatment of melasma.
Treatment of Melasma with Topical Agents, Peels and Lasers: An Evidence-Based Review
TLDR
An evidence-based review of interventions available for the treatment of melasma found topical depigmenting agents were found to be the most effective in treating moderate-to-severe melasma, with combination therapies, such as triple-combination therapy, yielding the best results.
Evaluation of the efficacy of cysteamine 5% cream in the treatment of epidermal melasma: a randomized double‐blind placebo‐controlled trial
Melasma is a difficult‐to‐treat hyperpigmentary disorder. While cysteamine is a known potent depigmenting agent, its efficacy in treating melasma has not been tested.
Melasma: Treatment strategy
TLDR
Melasma, a hypermelanosis of the face, is a common skin problem of middle-aged women of all racial groups, especially with dark complexion, and genetic influences, exposure to sunlight, pregnancy, oral contraceptives, estrogen-progesterone therapies, thyroid dysfunction, cosmetics, and drugs have been proposed.
Safety and efficacy of 4% hydroquinone combined with 10% glycolic acid, antioxidants, and sunscreen in the treatment of melasma
TLDR
Glycolic acid has been added to hydroquinone formulations in the past to enhance their depigmentation effects, but may cause irritation, leading to postinflammatory hyperpigmentation.
Depigmentation of black guinea pig skin by topical application of cysteaminylphenol, cysteinylphenol, and related compounds.
TLDR
Depigmentation of black skin by 4-S-CAP appeared to derive from a decreases in the number of functioning melanocytes; a decrease in theNumber of melanosomes synthesized within the melanocytes and transferred to keratinocytes; and destruction of the membranous organelles of the melanocyte.
A new formula for depigmenting human skin.
TLDR
The formula was therapeutically effective in treatment of melasma, ephelides, and postinflammatory hyperpigmentation and Senile lentigines were resistant to this therapy.
Increased human dermal microvascular endothelial cell survival induced by cysteamine
TLDR
Cysteamine concentrations, similar to those described in plasma of cystinosis patients, stimulate HDMVEC viability and proliferation and increase intracellular GSH content.
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