Significant role of apoptosis in type-1 autoimmune hepatitis.

  title={Significant role of apoptosis in type-1 autoimmune hepatitis.},
  author={Hideo Masuichi and Shuichi Seki and Takuya Kitada and Norifumi Kawada and Hiroki Sakaguchi and Kazuki Nakatani and Takeyuki Monna and Toshio Kuroki},
  journal={Osaka city medical journal},
  volume={45 1},
We used the terminal deoxyribonucleotidyl transferase-mediated deoxyuridine triphosphate-digoxigenin nick-end labeling (TUNEL) method to detect apoptosis, and immunohistochemical staining for molecules related to apoptosis, a marker of cell proliferation, and surface markers of lymphocytes to examine 20 patients with autoimmune hepatitis (AIH). Confluent hepatic necrosis was frequently found, in which rosette formation of hepatocytes and ductular proliferation were common. TUNEL staining and… CONTINUE READING