Significant linkage disequilibrium and high genetic diversity in a population of Plasmodium falciparum from an area (Republic of the Congo) highly endemic for malaria.

@article{Durand2003SignificantLD,
  title={Significant linkage disequilibrium and high genetic diversity in a population of Plasmodium falciparum from an area (Republic of the Congo) highly endemic for malaria.},
  author={Patrick Durand and Yannis Michalakis and S Cestier and Bruno Oury and Marie Claude Leclerc and Michel Tibayrenc and François N.R. Renaud},
  journal={The American journal of tropical medicine and hygiene},
  year={2003},
  volume={68 3},
  pages={345-9}
}
A study based on 28 microsatellite loci was performed on 32 isolates of Plasmodium falciparum from Pointe Noire (Republic of the Congo) and compared with a cosmopolitan sample of 21 isolates collected from different countries in Africa, Latin America, and Asia. The Pointe Noire population exhibited very high genetic diversity (A = 7.8 +/- 2.6, He = 0.79 +/- 0.11). Significant linkage disequilibria were observed in 28 of 378 pairs of microsatellite loci. This result could be explained by two non… CONTINUE READING

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Genetic diversity and population structure of Plasmodium falciparum isolates of Dakar, Senegal, investigated from microsatellite and antigen determinant loci

  • MC Leclerc, P Durand, T de Meeus, V Robert, F Renaud
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