Significant inter- and intra-laboratory variation in grading of ductal carcinoma in situ of the breast: a nationwide study of 4901 patients in the Netherlands

@article{Dooijeweert2018SignificantIA,
  title={Significant inter- and intra-laboratory variation in grading of ductal carcinoma in situ of the breast: a nationwide study of 4901 patients in the Netherlands},
  author={C. van Dooijeweert and P. V. van Diest and S. Willems and C. Kuijpers and L. Overbeek and I. Deckers},
  journal={Breast Cancer Research and Treatment},
  year={2018},
  volume={174},
  pages={479 - 488}
}
PurposeA considerable part of ductal carcinoma in situ (DCIS) lesions may never progress into invasive breast cancer. However, standard treatment consists of surgical excision. Trials aim to identify a subgroup of low-risk DCIS patients that can safely forgo surgical treatment based on histologic grade, which highlights the importance of accurate grading. Using real-life nationwide data, we aimed to create insight and awareness in grading variation of DCIS in daily clinical practice.MethodsAll… Expand
Grading Ductal Carcinoma In Situ (DCIS) of the Breast – What’s Wrong with It?
Ductal Carcinoma in Situ: A French National Survey. Analysis of 2125 Patients.
Patterns of treatment and outcome of ductal carcinoma in situ in the Netherlands
The effect of an e-learning module on grading variation of (pre)malignant breast lesions
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