Significant increase in anxiety during aging in mGlu5 receptor knockout mice

@article{Inta2013SignificantII,
  title={Significant increase in anxiety during aging in mGlu5 receptor knockout mice},
  author={Dragos Ioan Inta and Miriam A Vogt and Alessia Luoni and Dragana Filipovi{\'c} and Peter Gass},
  journal={Behavioural Brain Research},
  year={2013},
  volume={241},
  pages={27-31}
}
Glutamatergic mechanisms regulate neuronal circuits implicated in mood and anxiety. Emotional disorders as anxiety and depression are particularly difficult to treat during aging and mechanisms underlying emotional disturbances in the brain of the elderly are poorly understood. This may result from the small number of studies investigating these disorders in aged animals. Among glutamate receptors, metabotropic mGlu5 receptors are thought to play an important role, since their pharmacological… CONTINUE READING
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