Significant evidence of one or more susceptibility loci for endometriosis with near-Mendelian inheritance on chromosome 7p13-15.

@article{Zondervan2007SignificantEO,
  title={Significant evidence of one or more susceptibility loci for endometriosis with near-Mendelian inheritance on chromosome 7p13-15.},
  author={Krina T Zondervan and Susan A. Treloar and Jianghai Lin and Daniel E. Weeks and Dale R. Nyholt and Jon Mangion and Ian J Mackay and Lon R. Cardon and Nicholas G. Martin and Stephen H. Kennedy and Grant W. Montgomery},
  journal={Human reproduction},
  year={2007},
  volume={22 3},
  pages={717-28}
}
BACKGROUND Endometriosis is a common disease with a heritable component. The collaborative International Endogene Study consists of two data sets (Oxford and Australia) comprising 1176 families with multiple affected. The aim was to investigate whether the apparent concentration of cases in a proportion of families could be explained by one or more rare variants with (near-)Mendelian autosomal inheritance. METHODS AND RESULTS Linkage analyses (aimed at finding chromosomal regions harbouring… CONTINUE READING