Significant downregulation of the major swine xenoantigen by N-acetylglucosaminyltransferase III gene transfection.

Abstract

Introduction of the beta-D-mannoside beta-1,4-N-acetylglucosaminyltransferase III (GnT-III) gene into swine endothelial cells (SEC) reduced their susceptibility to normal human serum (NHS) in complement-mediated cell lysis and also suppressed the antigenicity to human natural antibodies as evidenced by flow cytometric analysis, as well as Griffonia… (More)

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@article{Tanemura1997SignificantDO, title={Significant downregulation of the major swine xenoantigen by N-acetylglucosaminyltransferase III gene transfection.}, author={Motoki Tanemura and S. Miyagawa and Yuki Ihara and H Matsuda and Ryota Shirakura and N. Taniguchi}, journal={Biochemical and biophysical research communications}, year={1997}, volume={235 2}, pages={359-64} }