Significant differential effects of hormone therapy or tibolone on markers of cardiovascular disease in postmenopausal women: a randomized, double-blind, placebo-controlled, crossover study.

@article{Koh2003SignificantDE,
  title={Significant differential effects of hormone therapy or tibolone on markers of cardiovascular disease in postmenopausal women: a randomized, double-blind, placebo-controlled, crossover study.},
  author={Kwang Kon Koh and Jeong Yeal Ahn and Dong Kyu Jin and B K Yoon and Hyung Sik Kim and Dae Sung Kim and Woong Chol Kang and Seung Hwan Han and In Suck Choi and Eak Kyun Shin},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2003},
  volume={23 10},
  pages={1889-94}
}
OBJECTIVE The objective was to compare the effects of tibolone and hormone therapy (HT) on lipid profile, vasodilation, and factors associated with inflammation and hemostasis. METHODS AND RESULTS Fifty-three women received micronized progesterone (MP, 100 mg) with conjugated equine estrogen (CEE, 0.625 mg) or tibolone (2.5 mg) daily for 2 months, with a 2-month washout period. Compared with HT, tibolone significantly reduced total cholesterol (P<0.001), triglyceride (P<0.001), and HDL… CONTINUE READING
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