Significant differences in B-cell subpopulations characterize patients with chronic graft-versus-host disease-associated dysgammaglobulinemia.

@article{Kuzmina2011SignificantDI,
  title={Significant differences in B-cell subpopulations characterize patients with chronic graft-versus-host disease-associated dysgammaglobulinemia.},
  author={Z. S. Kuzmina and Hildegard T. Greinix and Roman Weigl and Ulrike Koermoeczi and Arno Rottal and Sophie Frantal and Sandra Brigitte Eder and Winfried F. Pickl},
  journal={Blood},
  year={2011},
  volume={117 7},
  pages={
          2265-74
        }
}
Manifestations of chronic graft-versus-host disease (cGVHD) can resemble those seen in immunodeficiency states and autoimmune disorders. Reports by us and others suggest an involvement of B cells in the pathogenesis of cGVHD. We investigated B-lymphocyte subpopulations in cGVHD cohorts defined by serum immunoglobulin G (IgG) levels to characterize novel biomarkers for impairment of humoral immunity after allogeneic hematopoietic stem cell transplantation. Seventy-six patients were enrolled a… CONTINUE READING
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Citations

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CD19+CD21low B cells and CD4+CD45RA+CD31+ T cells correlate with first diagnosis of chronic graft-versus-host disease.

  • Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
  • 2015
VIEW 6 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

The lack of memory B cells including T cell independent IgM+ IgD+ memory B cells in chronic graft-versus host disease is associated with susceptibility to infection.

  • Transplant international : official journal of the European Society for Organ Transplantation
  • 2012
VIEW 4 EXCERPTS
CITES RESULTS & BACKGROUND
HIGHLY INFLUENCED

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