Significant curative functions of the mesenchymal stem cells on methotrexate‐induced kidney and liver injuries in rats

@article{Gad2017SignificantCF,
  title={Significant curative functions of the mesenchymal stem cells on methotrexate‐induced kidney and liver injuries in rats},
  author={Amany M Gad and Wedad A. Hassan and Ebtehal Mohammad Fikry},
  journal={Journal of Biochemical and Molecular Toxicology},
  year={2017},
  volume={31}
}
Mesenchymal stem cells (MSCs) curative effects on methotrexate (MTX)‐induced kidney and liver injuries remain elusive. Therefore, rats were divided into five groups, rats received MTX orally (14 mg/kg) as a single dose/week for 2 weeks, groups 3 and 4 were injected once with 2 × 106 cells bone marrow MSCs and adipose‐derived MSCs, respectively. The last group administered dexamethasone (DEX) (0.5 mg/kg, p.o) for 7 days. MTX caused marked increase in malondialdehyde and nitrite/nitrate… Expand
Role of Mesenchymal Stem Cells in the Treatment of Testicular Toxicity Induced by Lambda-Cyhalothrin in Rats
The present study aimed to investigate the therapeutic effects of mesenchymal stem cells (MSCs) on lambda-cyhalothrin (LCT)-induced testicular toxicity in rats. Thirty adult male rats were dividedExpand
Vanillin mitigates the adverse impact of cisplatin and methotrexate on rat kidneys
TLDR
In conclusion, VLN significantly protected against CSN- and MTX-induced kidney injury in rats by inhibiting oxidative/nitrosative stress, inflammation, and apoptosis. Expand
Breast Milk MSCs Transplantation Attenuates Male Diabetic Infertility Via Immunomodulatory Mechanism in Rats
| Diabetes is considered one of the most progressive metabolic syndrome that affects up to 7% of the people worldwide with many complications. Although the exact molecular mechanisms involved areExpand
Evaluation of the effect of methotrexate on the hippocampus, cerebellum, liver, and kidneys of adult male albino rat: Histopathological, immunohistochemical and biochemical studies.
TLDR
The ability of MTX to induce oxidative stress that results into apoptosis and tissue injury, leading to neurotoxicity, hepatotoxicity, and nephrotoxicity is concluded. Expand
Nephroprotective Effect of Mesenchymal Stem Cell-Based Therapy of Kidney Disease Induced by Toxicants
TLDR
A meta-analysis to assess the nephroprotective effect of mesenchymal stem cells (MSCs) in the treatment of kidney disease induced by toxicants indicates that MSCs may be a promising therapeutic agent for kidney diseaseinduced byoxicants. Expand
The current understanding of mesenchymal stem cells as potential attenuators of chemotherapy‐induced toxicity
TLDR
A concise review of the published data regarding the influence of various classes of chemotherapeutic agents on the survival, stem cell characteristics and physiological functions of MSCs is presented. Expand
Protective effects of Glycyrrhiza glabra supplementation against methotrexate-induced hepato-renal damage in rats: an experimental approach.
TLDR
It is suggested that GGE can alleviate MTX-induced hepato-renal damage by decreasing oxidative stress and suppressing the ensuing activation of pro-apoptotic and pro-inflammatory pathways. Expand
Renoprotective effects of umbelliferone on methotrexate-induced renal injury through regulation of Nrf-2/Keap-1, P38MAPK/NF-κB, and apoptosis signaling pathways.
TLDR
UMB possess marked renoprotective effects against MTX-induced renal damage through modulating oxidative stress, inflammation and apoptosis with enhancement of its cytotoxic activity. Expand
Concise Review: Using Fat to Fight Disease: A Systematic Review of Nonhomologous Adipose‐Derived Stromal/Stem Cell Therapies
TLDR
SVF and ASC are promising therapies for a variety of human diseases, particularly for patients with severe cases refractory to current medical treatments, and further randomized controlled trials must be performed to elaborate potential safety and efficacy prior to clinical use. Expand
Using Fat to Fight Disease: A Systematic Review of Non-Homologous Adipose- Derived Stromal/Stem Cell Therapies Running Head of Title: Using Fat to Fight Disease
Objective: The objective of this review is to describe the safety and efficacy of ASC and SVF in treating common diseases and the next steps in research that must occur prior to clinical use.Expand

References

SHOWING 1-10 OF 63 REFERENCES
Mesenchymal Stem Cells Attenuate Renal Fibrosis Through Immune Modulation and Remodeling Properties in a Rat Remnant Kidney Model
TLDR
Results suggested that MSC therapy can indeed modulate the inflammatory response that follows the initial phase of a chronic renal injury. Expand
Intravenous injection of mesenchymal stem cells is effective in treating liver fibrosis.
TLDR
The results of histopathological staining, immunohistochemistry, and biochemical analysis indicated that intravenous injection is more effective at rescuing liver failure than other injection modalities. Expand
Bone marrow-derived mesenchymal stem cells protect against experimental liver fibrosis in rats.
TLDR
MSCs treatment can protect against experimental liver fibrosis in CCl4-induced or DMN-induced rats and the mechanisms of the anti-fibrosis by MSCs will be studied further. Expand
Bone Marrow-Derived Mesenchymal Stem Cells Ameliorate Hepatic Ischemia Reperfusion Injury in a Rat Model
TLDR
The data suggest that MSC transplantation provides trophic support to the I/R-injured liver by inhibiting hepatocellular apoptosis and by stimulating regeneration. Expand
Allogeneic bone marrow-derived mesenchymal stem cells attenuate hepatic ischemia-reperfusion injury by suppressing oxidative stress and inhibiting apoptosis in rats.
TLDR
Bone marrow-derived mesenchymal stem cells transplanted via the portal vein partially prevent hepatic IR injury by suppressing oxidative stress and inhibiting apoptosis during the first 24 h after reperfusion. Expand
Mesenchymal stem cells ameliorate tissue damages triggered by renal ischemia and reperfusion injury.
TLDR
Results showed an antiinflammatory pattern in MSC-treated animals, demonstrating the potential of MSC to modulate I/R, leading to earlier regeneration of damaged renal tissue. Expand
Mesenchymal stem cell–derived molecules directly modulate hepatocellular death and regeneration in vitro and in vivo
TLDR
These data provide the first clear evidence that MSC‐CM therapy provides trophic support to the injured liver by inhibiting hepatocellular death and stimulating regeneration, potentially creating new avenues for the treatment of FHF. Expand
Mechanisms of Thymoquinone Hepatorenal Protection in Methotrexate-Induced Toxicity in Rats
TLDR
Using TQ concurrently with MTX restored kidney and liver functions, as well as their normal histology, and TQ may be beneficial adjuvant that confers hepatorenal protection to MTX toxicity via antioxidant, antinitrosative, anti-inflammatory, and antiapoptotic mechanisms. Expand
Human umbilical cord mesenchymal stem cells improve liver function and ascites in decompensated liver cirrhosis patients
TLDR
Umbilical cord‐derived MSC transfusion is clinically safe and could improve liver function and reduce ascites in patients with decompensated LC, therefore, UC‐MSC transfusion might present a novel therapeutic approach for patients with deconsecrated LC. Expand
Effect of whole bone marrow cell infusion in the progression of experimental chronic renal failure.
TLDR
The results showed that progression of CRF in rats could be slowed/stabilized by intrarenal parenchymal injection of MoSCs, and a trend toward reduction in the progression rate ofCRF was also observed with injection of MSCs. Expand
...
1
2
3
4
5
...