Significant curative functions of the mesenchymal stem cells on methotrexate‐induced kidney and liver injuries in rats

  title={Significant curative functions of the mesenchymal stem cells on methotrexate‐induced kidney and liver injuries in rats},
  author={Amany M Gad and Wedad A. Hassan and Ebtehal Mohammad Fikry},
  journal={Journal of Biochemical and Molecular Toxicology},
Mesenchymal stem cells (MSCs) curative effects on methotrexate (MTX)‐induced kidney and liver injuries remain elusive. Therefore, rats were divided into five groups, rats received MTX orally (14 mg/kg) as a single dose/week for 2 weeks, groups 3 and 4 were injected once with 2 × 106 cells bone marrow MSCs and adipose‐derived MSCs, respectively. The last group administered dexamethasone (DEX) (0.5 mg/kg, p.o) for 7 days. MTX caused marked increase in malondialdehyde and nitrite/nitrate… Expand
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