Significant behavioral disturbances in succinic semialdehyde dehydrogenase (SSADH) deficiency (Gamma-Hydroxybutyric aciduria)

@article{Gibson2003SignificantBD,
  title={Significant behavioral disturbances in succinic semialdehyde dehydrogenase (SSADH) deficiency (Gamma-Hydroxybutyric aciduria)},
  author={K Michael Gibson and Maneesh Kumar Gupta and Phillip Lawrence Pearl and Mendel Tuchman and L. Gilbert Vezina and O. C. Snead and Leo M. E. Smit and Cornelis Jakobs},
  journal={Biological Psychiatry},
  year={2003},
  volume={54},
  pages={763-768}
}
We report two adult patients with succinic semialdehyde dehydrogenase deficiency, manifesting as gamma-hydroxybutyric aciduria. For both, the clinical presentation included significant behavioral disturbances and psychosis (hallucinations, disabling anxiety, aggressive behavior, and sleep disorder), leading to multiple therapeutic attempts. Intervention with benzodiazepines appeared most efficacious, resulting in decreased aggression and agitation and improvement in anxiety. A review of 56… CONTINUE READING
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