Significant association of oncogene YAP1 with poor prognosis and cetuximab resistance in colorectal cancer patients.

@article{Lee2015SignificantAO,
  title={Significant association of oncogene YAP1 with poor prognosis and cetuximab resistance in colorectal cancer patients.},
  author={Keun-Wook Lee and Sung Sook Lee and Sang-Bae Kim and Bo Hwa Sohn and Hyun-Sung Lee and Hee-Jin Jang and Y. Park and Scott Kopetz and Sung Soo Kim and Sang Cheul Oh and Ju-Seog Lee},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2015},
  volume={21 2},
  pages={357-64}
}
PURPOSE Activation of YAP1, a novel oncogene in the Hippo pathway, has been observed in many cancers, including colorectal cancer. We investigated whether activation of YAP1 is significantly associated with prognosis or treatment outcomes in colorectal cancer. EXPERIMENTAL DESIGN A gene expression signature reflecting YAP1 activation was identified in colorectal cancer cells, and patients with colorectal cancer were stratified into two groups according to this signature: activated YAP1… CONTINUE READING
Highly Cited
This paper has 73 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 32 extracted citations

Potential biomarkers for anti-EGFR therapy in metastatic colorectal cancer

Tumor Biology • 2016
View 3 Excerpts
Highly Influenced

Emerging role of Hippo signalling pathway in bladder cancer

Journal of cellular and molecular medicine • 2018
View 1 Excerpt

Colorectal cancer: epigenetic alterations and their clinical implications.

Biochimica et biophysica acta. Reviews on cancer • 2017
View 1 Excerpt

74 Citations

0204020152016201720182019
Citations per Year
Semantic Scholar estimates that this publication has 74 citations based on the available data.

See our FAQ for additional information.

Similar Papers

Loading similar papers…