Significant association of a single nucleotide polymorphism in the tumor necrosis factor-alpha (TNF-alpha) gene promoter with human narcolepsy.

@article{Hohjoh1999SignificantAO,
  title={Significant association of a single nucleotide polymorphism in the tumor necrosis factor-alpha (TNF-alpha) gene promoter with human narcolepsy.},
  author={Hirohiko Hohjoh and Tomohiro Nakayama and Jun Ohashi and Taku Miyagawa and Hiroshi Tanaka and Tatsuya Akaza and Yutaka Honda and Takeo Juji and Katsushi Tokunaga},
  journal={Tissue antigens},
  year={1999},
  volume={54 2},
  pages={138-45}
}
Narcolepsy is a sleep disorder in which multiple factors, including environmental and genetic factors, are involved. A genetic factor strongly associated with the disorder has been found in the human leukocyte antigen (HLA) class II region: the haplotype, DRB1*1501-DQB1*0602, predisposes to narcolepsy. No susceptibility genes other than the HLA-haplotype have been found. In this paper, we performed an association study of the tumor necrosis factor-alpha (TNF-alpha) gene located in the HLA class… CONTINUE READING

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