Significant association of TH01 allele 9.3 and SIDS.

  title={Significant association of TH01 allele 9.3 and SIDS.},
  author={Cornelius Courts and Burkhard Madea},
  journal={Journal of forensic sciences},
  volume={56 2},
Sudden infant death syndrome (SIDS) constitutes a considerable percentage of infant death of unknown etiology. Individual catecholamine response variation is suspected to play a role in SIDS. TH01 is a tetrameric short tandem repeat marker in the tyrosine hydroxylase gene, which regulates gene expression and catecholamine production with allele 9.3 exerting a particularly strong effect on noradrenaline production. We investigated in an age-controlled study the TH01 allele frequencies in 127… CONTINUE READING