Significant association of Rho/ROCK pathway with invasion and metastasis of bladder cancer.

@article{Kamai2003SignificantAO,
  title={Significant association of Rho/ROCK pathway with invasion and metastasis of bladder cancer.},
  author={Takao Kamai and Toshihiko Tsujii and Kyoko Arai and Kentaro Takagi and Hidekazu Asami and Yuji Ito and Hiroyuki Oshima},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2003},
  volume={9 7},
  pages={
          2632-41
        }
}
PURPOSE The small GTP-binding protein Rho and its best-characterized downstream effector Rho-associated serine-threonine protein kinase, ROCK, participate in actin cytoskeleton organization, and are linked to pathogenesis and progression of several human tumors. We investigated the roles of Rho and ROCK in bladder cancer. EXPERIMENTAL DESIGN Using Western blotting, we quantitated Rho and ROCK protein expression in paired tumor and nontumor surgical samples from 107 consecutive Japanese… CONTINUE READING

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