Significant association of Interleukin-10 genotypes and oral cancer susceptibility in Taiwan.

@article{Tsai2014SignificantAO,
  title={Significant association of Interleukin-10 genotypes and oral cancer susceptibility in Taiwan.},
  author={Chia-Wen Tsai and W -H Chang and Kuo-Cheng Lin and Liang-Chun Shih and Ming-Hsui Tsai and Chieh-Lun Hsiao and M T Yang and C T Lin and Da-Tian Bau},
  journal={Anticancer research},
  year={2014},
  volume={34 7},
  pages={3731-7}
}
Interleukin-10 (IL10) is an immunosuppressive cytokine which may facilitate carcinogenesis by down-regulating interferon-gamma production and supporting tumor escape from the immune response. Polymorphisms within the promoter of IL10 gene may not only contribute to differential IL10 expression levels among individuals but also to oral cancer susceptibility. In this hospital-based study, the association of IL10 A-1082G (rs1800896), T-819C (rs3021097), and A-592C (rs1800872) polymorphisms with… CONTINUE READING
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