Significant association of BDNF haplotypes in European-American male smokers but not in European-American female or African-American smokers.

@article{Beuten2005SignificantAO,
  title={Significant association of BDNF haplotypes in European-American male smokers but not in European-American female or African-American smokers.},
  author={Joke Beuten and Jennie Z Ma and Thomas J. Payne and Randolph T. Dupont and Paulina Quezada and Weihua Huang and Karen M. Crews and Ming D. Li},
  journal={American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics},
  year={2005},
  volume={139B 1},
  pages={73-80}
}
Brain-derived neurotrophic factor (BDNF) influences dopamine and serotonin neurotransmission in the brain, both of which are involved in the reward system of addiction. The BDNF gene is located in a genomic region on chromosome 11p where we and others have found 'significant' linkage to nicotine dependence (ND). We tested the potential role of variants within BDNF in vulnerability to ND, which was assessed by Smoking Quantity (SQ), the Heaviness of Smoking Index (HSI), and the Fagerström Test… CONTINUE READING

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