Significant association between toll-like receptor gene polymorphisms and gallbladder cancer.

  title={Significant association between toll-like receptor gene polymorphisms and gallbladder cancer.},
  author={Kshitij Srivastava and Anvesha Srivastava and Ashok Kumar and Balraj Mittal},
  journal={Liver international : official journal of the International Association for the Study of the Liver},
  volume={30 7},
BACKGROUND Toll-like receptors (TLRs) are evolutionarily conserved cell surface receptors of innate immune system. Various polymorphisms in TLR genes have been identified and associated with susceptibility toward various malignancies such as prostate cancer, gastric cancer and colorectal cancer. The present study was undertaken to examine the potential association of two polymorphisms in TLR2 and TLR4 genes with gallbladder cancer (GBC) susceptibility. METHODS Genotypes and allelic… CONTINUE READING


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