Significant Prognostic Features and Patterns of Somatic TP53 Mutations in Human Cancers

  title={Significant Prognostic Features and Patterns of Somatic TP53 Mutations in Human Cancers},
  author={W. Zhang and Andrea Edwards and E. Flemington and K. Zhang},
  journal={Cancer Informatics},
  • W. Zhang, Andrea Edwards, +1 author K. Zhang
  • Published 2017
  • Medicine
  • Cancer Informatics
  • TP53 is the most frequently altered gene in human cancers. Numerous retrospective studies have related its mutation and abnormal p53 protein expression to poor patient survival. Nonetheless, the clinical significance of TP53 (p53) status has been a controversial issue. In this work, we aimed to characterize TP53 somatic mutations in tumor cells across multiple cancer types, primarily focusing on several less investigated features of the mutation spectra, and determine their prognostic… CONTINUE READING
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