Significant Prognostic Features and Patterns of Somatic TP53 Mutations in Human Cancers

@article{Zhang2017SignificantPF,
  title={Significant Prognostic Features and Patterns of Somatic TP53 Mutations in Human Cancers},
  author={W. Zhang and Andrea Edwards and E. Flemington and K. Zhang},
  journal={Cancer Informatics},
  year={2017},
  volume={16}
}
  • W. Zhang, Andrea Edwards, +1 author K. Zhang
  • Published 2017
  • Medicine
  • Cancer Informatics
  • TP53 is the most frequently altered gene in human cancers. Numerous retrospective studies have related its mutation and abnormal p53 protein expression to poor patient survival. Nonetheless, the clinical significance of TP53 (p53) status has been a controversial issue. In this work, we aimed to characterize TP53 somatic mutations in tumor cells across multiple cancer types, primarily focusing on several less investigated features of the mutation spectra, and determine their prognostic… CONTINUE READING
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    References

    SHOWING 1-10 OF 58 REFERENCES
    Prognostic significance of mutations to different structural and functional regions of the p53 gene in breast cancer.
    • 75
    • PDF
    TP53 mutations in human cancers: origins, consequences, and clinical use.
    • 1,059
    • PDF
    p53 mutations in defined structural and functional domains are related to poor clinical outcome in non-small cell lung cancer patients.
    • V. Skaug, D. Ryberg, +4 authors A. Haugen
    • Biology, Medicine
    • Clinical cancer research : an official journal of the American Association for Cancer Research
    • 2000
    • 96
    Clinical outcomes and correlates of TP53 mutations and cancer.
    • 207
    • PDF
    High-throughput oncogene mutation profiling in human cancer
    • 966
    • PDF
    TP53 mutations and survival in squamous-cell carcinoma of the head and neck.
    • 587