Significant Improvement in Cognition in Mild to Moderately Severe Dementia Cases Treated with Transcranial Plus Intranasal Photobiomodulation: Case Series Report

@article{Saltmarche2017SignificantII,
  title={Significant Improvement in Cognition in Mild to Moderately Severe Dementia Cases Treated with Transcranial Plus Intranasal Photobiomodulation: Case Series Report},
  author={Anita E. Saltmarche and Margaret A. Naeser and Kai Fai Ho and Michael R. Hamblin and Lew Lim},
  journal={Photomedicine and Laser Surgery},
  year={2017},
  volume={35},
  pages={432 - 441}
}
Abstract Objective: This study investigated whether patients with mild to moderately severe dementia or possible Alzheimer's disease (AD) with Mini-Mental State Exam (MMSE) Baseline scores of 10–24 would improve when treated with near-infrared photobiomodulation (PBM) therapy. Background: Animal studies have presented the potential of PBM for AD. Dysregulation of the brain's default mode network (DMN) has been associated with AD, presenting the DMN as an identifiable target for PBM. Materials… 

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References

SHOWING 1-10 OF 45 REFERENCES
The Effect of Memantine on Cognitive Function and Behavioral and Psychological Symptoms in Mild-to-Moderate Alzheimer's Disease Patients
TLDR
Findings support the efficacy of memantine for the treatment of mild-to-moderate AD, especially in patients with agitation, as well as the score of the Clinician's Interview-Based Impression of Change plus Caregiver Input.
A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Alzheimer's disease
TLDR
The data indicate that donepezil is a well-tolerated drug that improves cognition and global function in patients with mild to moderate AD.
The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease
TLDR
In patients with prodromal or mild AD, one year of monthly intravenous infusions of aducanumab reduces brain Aβ in a dose- and time-dependent manner, accompanied by a slowing of clinical decline measured by Clinical Dementia Rating—Sum of Boxes and Mini Mental State Examination scores.
Psychological benefits 2 and 4 weeks after a single treatment with near infrared light to the forehead: a pilot study of 10 patients with major depression and anxiety
TLDR
This small feasibility study suggests that NIR-PBM may have utility for the treatment of depression and other psychiatric disorders and that double blind randomized placebo-controlled trials are indicated.
Focal increase in cerebral blood flow after treatment with near-infrared light to the forehead in a patient in a persistent vegetative state.
TLDR
Transcranial LED might increase rCBF with some improvement of neurological condition in severely head-injured patients, and some improvement in his neurological condition by moving his left arm/hand to reach the tracheostomy tube, post-LED therapy.
A phase II trial of huperzine A in mild to moderate Alzheimer disease
TLDR
This study provides Class III evidence that huperzine A 200 μg BID has no demonstrable cognitive effect in patients with mild to moderate AD.
Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer's disease
TLDR
The fMRI variant used to address basic questions about entorhinal cortex pathophysiology found that the LEC was affected in preclinical disease, that LEC dysfunction could spread to the parietal cortex duringPreclinical disease and that APP expression potentiated tau toxicity in driving L EC dysfunction, thereby helping to explain regional vulnerability in the disease.
Photobiomodulation with near infrared light mitigates Alzheimer’s disease-related pathology in cerebral cortex – evidence from two transgenic mouse models
TLDR
The results suggest that NIr may have potential as an effective, minimally-invasive intervention for mitigating, and even reversing, progressive cerebral degenerations.
Amyloid-β--associated clinical decline occurs only in the presence of elevated P-tau.
TLDR
A-associated clinical decline during a mean of 3 years may occur only in the presence of ongoing downstream neurodegeneration in cognitively normal older individuals.
Default-mode network activity distinguishes Alzheimer's disease from healthy aging: Evidence from functional MRI
TLDR
A goodness-of-fit analysis applied at the individual subject level suggests that activity in the default-mode network may ultimately prove a sensitive and specific biomarker for incipient AD.
...
...