Significant IgG-immunoreactivity of the spermatogonia of the germ cell-depleted testis after busulfan treatment.

@article{Choi2006SignificantIO,
  title={Significant IgG-immunoreactivity of the spermatogonia of the germ cell-depleted testis after busulfan treatment.},
  author={Yun-Jung Choi and Hyuk Song and Deug-Nam Kwon and Seong-Keun Cho and Sung-Jo Kang and Sung-Moon Yoe and H Kim and Hoon Taek Lee and Chankyu Park and Jin-hoi Kim},
  journal={Animal reproduction science},
  year={2006},
  volume={91 3-4},
  pages={317-35}
}
Busulfan kills spermatogonia with the exception of a few that are attached to the basal membrane of the seminiferous epithelium. In mice, these remaining spermatogonia reacted strongly to a goat anti-mouse IgG antibody. Spermatogonia in untreated testes rarely showed the same reactivity. Testicular IgG levels are normally minimal but increase markedly, 4 weeks after busulfan treatment before peaking at week 6. Laser scanning cytometry analysis of control and busulfan-treated testicular cells… CONTINUE READING
Highly Cited
This paper has 17 citations. REVIEW CITATIONS