Significance of transcytosis in Alzheimer's disease: BACE1 takes the scenic route to axons.

@article{BuggiaPrvot2015SignificanceOT,
  title={Significance of transcytosis in Alzheimer's disease: BACE1 takes the scenic route to axons.},
  author={Virginie Buggia-Pr{\'e}vot and Gopal Thinakaran},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  year={2015},
  volume={37 8},
  pages={888-98}
}
Neurons have developed elaborate mechanisms for sorting of proteins to their destination in dendrites and axons as well as dynamic local trafficking. Recent evidence suggests that polarized axonal sorting of β-site converting enzyme 1 (BACE1), a type I transmembrane aspartyl protease involved in Alzheimer's disease (AD) pathogenesis, entails an unusual journey. In hippocampal neurons, BACE1 internalized from dendrites is conveyed in recycling endosomes via unidirectional retrograde transport… CONTINUE READING