Significance of thymidylate synthase gene expression level in patients with adenocarcinoma of the lung

@article{Hashimoto2006SignificanceOT,
  title={Significance of thymidylate synthase gene expression level in patients with adenocarcinoma of the lung},
  author={Hiroshi Hashimoto and Yuichi Ozeki and Mitsuharu Sato and Kiyohaya Obara and Noriyuki Matsutani and Yoshinori Nakagishi and Toshiro Ogata and Tadaaki Maehara},
  journal={Cancer},
  year={2006},
  volume={106}
}
Thymidylate synthase (TS) catalyzes the methylation of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP) and is a key enzyme for DNA synthesis. High expression of TS is thought to be associated with poor prognosis in some kinds of cancers. However, this association has not been clarified for nonsmall cell lung carcinoma. In the current study, the authors investigated the clinicopathologic significance of TS mRNA levels and the correlation with cellular proliferation in… Expand
Higher Tissue Levels of Thymidylate Synthase Determined by ELISA Are Associated with Poor Prognosis of Patients with Lung Cancer.
TLDR
A significant correlation between low TS expression levels and long-term prognosis of patients with lung cancer is demonstrated and ELISA is a clinically useful method to measure TS and DPD expression in lung cancer tissues. Expand
Thymidylate synthase expression is closely associated with outcome in patients with pulmonary adenocarcinoma
TLDR
In AC patients, TS expression was significantly associated with advanced stage, lymph node metastases, vascular invasion, Glut1, HIF-1α, angiogenesis, EGFR signaling pathway and p53, while in patients with non-AC, TSexpression was not closely correlated with outcome and these biomarkers. Expand
Squamous cell carcinoma of the lung compared with other histotypes shows higher messenger RNA and protein levels for thymidylate synthase
In patients with cancer, one of the main mechanism of resistance to antimetabolite drugs is related to higher levels of thymidylate synthase (TS) activity.
Differential Thymidylate Synthase Expression in Different Variants of Large-Cell Carcinoma of the Lung
TLDR
The pulmonary LCC immunoprofile is associated with differential TS expression levels, which may support a more appropriate therapeutic strategy decision, and may resemble that of SCCs or ADCs. Expand
Thymidylate Synthase Protein Expression by IHC and Gene Copy Number by SISH Correlate and Show Great Variability in Non–Small Cell Lung Cancer
  • M. Wynes, K. Konopa, +7 authors F. Hirsch
  • Biology, Medicine
  • Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • 2012
TLDR
Variability of TS PE and GCN may indicate potential benefit from pemetrexed therapy in selected SCC patients and correlate significantly with each other in non–small cell lung. Expand
Association of thymidylate synthase gene 3'-untranslated region polymorphism with sensitivity of non-small cell lung cancer to pemetrexed treatment: TS gene polymorphism and pemetrexed sensitivity in NSCLC
TLDR
It is shown that TS protein is highly expressed in NSCLC and that polymorphisms of TS 3’-UTR 1494del 6 bp are associated with sensitivity of lung adenocarcinoma patients to pemetrexed treatment. Expand
Prognostic significance of thymidylate synthase in postoperative non-small cell lung cancer patients
TLDR
It is demonstrated that the TS level in tumor tissues may be a useful marker to predict the postoperative OS in NSCLC patients. Expand
Immunohistochemical characterization of pyrimidine synthetic enzymes, thymidine kinase-1 and thymidylate synthase, in various types of cancer.
TLDR
Investigation of the expression of TK-1 and TS in various types of cancer suggested that TAS-102 may also be effective for esophageal and uterine squamous cell carcinomas, as well as for gastrointestinal adenocarcinomas, even in fluoropyrimidine-resistant cases with high TS expression. Expand
Thymidylate synthase was associated with patient prognosis and the response to adjuvant therapy in bladder cancer
To investigate the expression of thymidylate synthase (TS), a key enzyme in DNA synthesis that is over‐expressed in several cancer cells, in bladder cancer and its association with patient prognosisExpand
Immunohistochemistry. Expression levels of the TS protein were detected by rabbit monoclonal anti-human thymidylate synthetase antibody
Chemotherapy represents an important treatment modality for lung adenocarcinoma. Thymidylate synthase (TS) is an essential enzyme in DNA synthesis, and its overexpression has been associated withExpand
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References

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Prognostic significance of thymidylate synthase activity in bladder carcinoma
TLDR
The authors investigated the activity of TS in 82 bladder cancers and prognostic significance of the levels of TS and/or activities of dihydropyrimidine dehydrogenase (DPD), an important enzyme in the degradation of 5‐FU. Expand
The role of thymidylate synthase levels in the prognosis and the treatment of patients with colorectal cancer.
TLDR
The hypothesis that a high TS level is a favourable prognostic factor in human untreated colorectal carcinomas according to previous preliminary data is supported. Expand
Prognostic Significance of the Thymidylate Biosynthetic Enzymes in Human Colorectal Tumors
TLDR
Combined evaluation of the two parameters proved that TK may contribute to the more precise assessment of disease prognosis, and it may further influence treatment decisions, i.e. the selection of patients for adjuvant therapy with 5-FU and folinic acid. Expand
Significance of thymidylate synthase activity in renal cell carcinoma.
  • Y. Mizutani, H. Wada, +4 authors T. Miki
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TLDR
The present study is the first study to demonstrate that the level of TS activity was correlated with both the progression of the stage and the increase of the grade of RCC, and that higher TS activity in primary cultured RCC predicted higher sensitivity to 5-FU. Expand
Thymidylate Synthase Expression in Epithelial Ovarian Cancer: Relationship with Thymidine Phosphorylase Expression and Prognosis
TLDR
TS and TP combined may indicate a poor prognosis for patients with epithelial ovarian cancer, and the relative risk of death for tumors with high TS and high TP expression was greater than that for either only high TS or high TP gene expression. Expand
p53 point mutations and thymidylate synthase messenger RNA levels in disseminated colorectal cancer: an analysis of response and survival.
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  • Biology, Medicine
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TLDR
Data is presented linking specific p53 point mutations to TS expression levels and resistance to 5-FU, as well as by the gene expression level of thymidylate synthase, the target enzyme of 5-fluorouracil, by reverse transcription-PCR. Expand
Expression of thymidylate synthase in relation to survival and chemosensitivity in gastric cancer patients.
TLDR
Results indicate that TS expression can be used as an independent prognostic factor for patients with gastric cancer, however, TS expression is not a major predictor of the efficacy of FU-based chemotherapy. Expand
Identification of a thymidylate synthase ribonucleoprotein complex in human colon cancer cells.
TLDR
It is shown that TS is complexed in vivo with its own TS RNA, and evidence demonstrating a direct interaction between the mRNA of the nuclear oncogene c-myc and TS protein is presented. Expand
Thymidylate synthetase and dihydropyrimidine dehydrogenase levels in gastric cancer.
TLDR
It is concluded that high tumoral TS levels and low tumoral DPD mRNA may indicate the selective cytotoxicity of 5-FU on gastric cancer, and that tumoralTS mRNA levels may be a prognostic factor for patients with stage III/IV Gastric cancer. Expand
Clinical significance of thymidylate synthase expression in bladder cancer
Background : The purpose of the present paper was to investigage the clinical significance of thymidylate synthase (TS) expression in bladder cancer and its association with proliferation markers,Expand
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