Significance of the parkin and PINK1 gene in Jordanian families with incidences of young-onset and juvenile parkinsonism

@article{Myhre2008SignificanceOT,
  title={Significance of the parkin and PINK1 gene in Jordanian families with incidences of young-onset and juvenile parkinsonism},
  author={Ronny Myhre and Stina Steinkjer and Alice Stormyr and Gina L Nilsen and Hiba Abu Zayyad and Khalid Horany and Mohamad K. Nusier and Helge Klungland},
  journal={BMC Neurology},
  year={2008},
  volume={8},
  pages={47 - 47}
}
BACKGROUND Parkinson's disease is a progressive neurodegenerative disorder, where most cases are sporadic with a late onset. In rare incidences familial forms of early-onset parkinsonism occur, and when recessively inherited, cases are often explained by mutations in either the parkin (PARK2) or PINK1 (PARK6) gene or on exceptional occasions the DJ-1 (PARK7) or ATP13A2 (PARK9) gene. Recessively inherited deletions/duplications and point mutations in the parkin gene are the most common cause of… CONTINUE READING