Significance of survivin mRNA expression in prognosis of neuroblastoma.

  title={Significance of survivin mRNA expression in prognosis of neuroblastoma.},
  author={Rie Ito and Satoru Asami and Shigeyasu Motohashi and Susumu Ootsuka and Yusuke Yamaguchi and Motoaki Chin and Hiroyuki Shichino and Yukihiro Yoshida and Norimichi Nemoto and Hideo Mugishima and Takashi Suzuki},
  journal={Biological & pharmaceutical bulletin},
  volume={28 4},
Neuroblastoma (NB) is the most common malignant solid tumor in childhood, and among all childhood malignancies is second in prevalence only to leukemia. In NB we need to both make an accurate diagnosis and rapidly analyze the expression of genetic prognostic factors such as MYCN, H-ras, and trkA. Moreover, it has recently become important to analyze the expression of survivin mRNA, a member of the inhibitor of apoptosis protein family. Expression of the survivin gene is related to tumorigenesis… CONTINUE READING


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