Significance of serum concentrations of E-selectin and CA19-9 in the prognosis of colorectal cancer.

Abstract

OBJECTIVE Interaction of CA19-9 with E-selectin is involved in initiation of hematogenous metastases. We investigated whether serum concentrations of E-selectin and CA19-9 are good predictors of hematogenous metastases and prognosis in colorectal cancer. METHODS Pre-operative serum samples were obtained from 152 patients with colorectal cancer, and from 28 healthy volunteers. Correlation between serum E-selectin and CA19-9 was studied in terms of clinically detected hematogenous metastases and prognosis of patients. RESULTS Low serum concentration of E-selectin was defined as <50 U/ml in healthy volunteers, and on that basis, 20.4% of all patients belonged to the high E-selectin group. Several distinctive characteristics were observed in the clinical course of patients with high serum concentrations of both CA19-9 and E-selectin. The rate of Dukes' D cancer was significantly higher, and curative surgery was performed less frequently in patients with high serum concentrations of both CA19-9 and E-selectin (60 and 40%) than in others. However, there was no significant difference in the frequency of recurrence after curative surgery between patients with high serum concentrations of both CA19-9 and E-selectin (25.0%) and others. Overall the 5-year survival rate was significantly lower in patients with high serum concentrations of both CA19-9 and E-selectin (34.3%) than in other patients. Even if the serum concentration of CA19-9 was high, prognosis was not poor in patients with low serum concentration of E-selectin. CONCLUSIONS These results suggested that it was useful to measure both CA19-9 and E-selectin as markers of hematogenous metastases and as predictors of prognosis in colorectal cancer.

DOI: 10.1093/jjco/hyq095

8 Figures and Tables

Statistics

0204060201220132014201520162017
Citations per Year

97 Citations

Semantic Scholar estimates that this publication has 97 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Sato2010SignificanceOS, title={Significance of serum concentrations of E-selectin and CA19-9 in the prognosis of colorectal cancer.}, author={Harunobu Sato and Nobuteru Usuda and Makoto Kuroda and Shuji Hashimoto and Morito Maruta and Koutarou Maeda}, journal={Japanese journal of clinical oncology}, year={2010}, volume={40 11}, pages={1073-80} }