Significance of serum CrossLaps as a predictor of changes in bone mineral density during estrogen replacement therapy; comparison with serum carboxyterminal telopeptide of type I collagen and urinary deoxypyridinoline

@article{Okabe2003SignificanceOS,
  title={Significance of serum CrossLaps as a predictor of changes in bone mineral density during estrogen replacement therapy; comparison with serum carboxyterminal telopeptide of type I collagen and urinary deoxypyridinoline},
  author={Reiko Okabe and Masaaki Inaba and Kiyoshi Nakatsuka and Takami Miki and Hiroshi Naka and Atushi Moriguchi and Yoshiki Nishizawa},
  journal={Journal of Bone and Mineral Metabolism},
  year={2003},
  volume={22},
  pages={127-131}
}
The newly developed Elecsys Β-CrossLaps/serum assay measures C-terminal telopeptide of type I collagen and has thus been proposed as a reliable serum marker for bone resorption. We investigated its usefulness for monitoring the therapeutic effect of estrogen replacement therapy on bone turnover and bone mineral density (BMD) in patients with postmenopausal osteoporosis. Serum Β-CTx decreased by 43.2% ± 9.2% (mean ± SD), and 55.1% ± 7.0% at 3 and 6 months, respectively, after initiation of… CONTINUE READING

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