Significance of schistosomal granuloma modulation.

@article{Silva2000SignificanceOS,
  title={Significance of schistosomal granuloma modulation.},
  author={L. Silva and A. L. Fernandes and A. Barbosa and I. Oliveira and Z. Andrade},
  journal={Memorias do Instituto Oswaldo Cruz},
  year={2000},
  volume={95 3},
  pages={
          353-61
        }
}
Hepatic Schistosoma mansoni periovular granulomas undergo changes in size, cellular composition and appearance with time. This phenomenon, known as "immunological modulation", has been thought to reflect host immunological status. However, as modulation has not been observed outside the liver, participation of local factors, hitherto little considered, seems crucial. Components of the extracellular matrix of periovular granulomas of the mouse were particularly studied in three different organs… Expand
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References

SHOWING 1-10 OF 33 REFERENCES
Experimental pulmonary schistosomiasis: lack of morphological evidence of modulation in schistosomal pulmonary granulomas.
TLDR
Pulmonary granulomas formed around mature eggs in the pulmonary alveolar tissue presented approximately the same size and morphology regardless of the time of infection, suggesting that pulmonary granuloma do not undergo immunological modulation, as is the case with thegranulomas in the liver and, to a lesser extent, in the intestines. Expand
Evolution of the schistosomal hepatic lesions in mice after curative chemotherapy.
TLDR
Specific treatment of schistosomiasis showed a beneficial effect upon the hepatic lesions from the very beginning and promoted changes in the periovular granulomas that indicated a rapid, although incomplete, resorption of fibrosis. Expand
Delayed hypersensitivity granuloma formation around Schistosoma mansoni eggs in vitro. I. Definition of the model.
TLDR
In vitro studies have demonstrated the immunologic specificity of the reaction, its dependence on an initial T lymphocyte-mediated event, and recruitment of other cell populations, and preliminary studies show that modulation in vitro reflects the in vivo kinetics of granuloma modulation. Expand
T lymphocytes that contribute to the immunoregulation of granuloma formation in chronic murine schistosomiasis.
  • D. Colley
  • Biology, Medicine
  • Journal of immunology
  • 1981
TLDR
A continuing supply of newly developed T lymphocytes appears to be required for the establishment and maintenance of a substantial portion of this immunoregulatory process in chronic infection. Expand
Organ-dependent differences in composition and function observed in hepatic and intestinal granulomas isolated from mice with Schistosomiasis mansoni.
TLDR
It appears that granuloma formation in various organs is influenced by local factors that could affect the ultimate resolution of the lesions, and colonic and ileal granulomas had weak or no MIF activity. Expand
In situ analysis of cytokine responses in experimental murine schistosomiasis.
TLDR
Observed cytokine patterns suggest that granulomas contain T lymphocytes of both the Th-1 and Th-2 types and that cytokine production occurs during a limited time in the early granuloma. Expand
WARREN KS: MILD PROLONGED SCHISTOSOMIASIS IN MICE: ALTERATIONS IN HOST RESPONSE WITH TIME AND THE DEVELOPMENT OF PORTAL FIBROSIS.
  • Z. Andrade
  • Biology, Medicine
  • Transactions of the Royal Society of Tropical Medicine and Hygiene
  • 1964
TLDR
Mice with mild prolonged infection with Schistosoma mansoni showed a considerable variation in the appearance of the hepatic granulomas appearing around mature eggs in the course of infection, interpreted as morphological expression of hypersensitivity and immunity developing in the Course of prolonged infection. Expand
Cytokine regulation of granuloma formation in schistosomiasis.
TLDR
It is clear from current data that the Th2 cytokines play a primary role in granuloma formation, whereas the Th1-associated lymphokine interferon-gamma acts as an endogenous downregulator of the response. Expand
Collagen isotypes, laminin, and fibronectin in granulomas of the liver and intestines of Schistosoma mansoni-infected mice.
TLDR
Observations indicate the existence of important organ-related differences in the intragranulomatous deposition of connective tissue matrix within hepatic and intestinal granulomas of Schistosoma mansoni-infected mice. Expand
Role of cytokines in the formation and downregulation of hepatic circumoval granulomas and hepatic fibrosis in Schistosoma mansoni-infected mice.
TLDR
In chronic infections immunologic downmodulation proceeded normally in mice without functional CD8+ cells and in IFN-gamma KO mice but not in B cell KO (microMT) mice or in mice deficient in FcR expression in spite of the fact that these mice downregulated their T cell and cytokine responses. Expand
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