Significance of promoter hypermethylation of p16 gene for margin assessment in carcinoma tongue

@article{Sinha2009SignificanceOP,
  title={Significance of promoter hypermethylation of p16 gene for margin assessment in carcinoma tongue},
  author={P. Sinha and S. Bahadur and A. Thakar and Ajay Matta and M. Macha and R. Ralhan and S. Datta Gupta},
  journal={Head & Neck},
  year={2009},
  volume={31}
}
  • P. Sinha, S. Bahadur, +4 authors S. Datta Gupta
  • Published 2009
  • Medicine
  • Head & Neck
  • Loss of p16 expression by promoter hypermethylation has been reported as an early event in the development of oral cancer. The aim of our study was to explore the prognostic implications of presence of promoter hypermethylation of p16 gene in surgical margins in carcinoma tongue. 

    Topics from this paper.

    Epigenetic mechanisms in oral carcinogenesis.
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    Role of DNA methylation in head and neck cancer
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    • Highly Influenced
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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 32 REFERENCES
    Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.
    • 5,567
    • Highly Influential
    • Open Access
    Gene promoter hypermethylation in tumors and serum of head and neck cancer patients.
    • 526
    • Open Access
    Frequent inactivation of p16INK4a in oral premalignant lesions
    • 173
    • Open Access