Significance of promoter hypermethylation of p16 gene for margin assessment in carcinoma tongue.

@article{Sinha2009SignificanceOP,
  title={Significance of promoter hypermethylation of p16 gene for margin assessment in carcinoma tongue.},
  author={Parul Sinha and Sudhir Bahadur and Alok Thakar and Ajay Matta and Muzafar Ahmad Macha and Ranju Ralhan and Siddhartha Datta Gupta},
  journal={Head & neck},
  year={2009},
  volume={31 11},
  pages={1423-30}
}
BACKGROUND Loss of p16 expression by promoter hypermethylation has been reported as an early event in the development of oral cancer. The aim of our study was to explore the prognostic implications of presence of promoter hypermethylation of p16 gene in surgical margins in carcinoma tongue. METHODS A prospective analysis of 38 patients with resectable carcinoma tongue was carried out. DNA from tumor and the surgical margins was assessed by methylation-specific polymerase chain reaction… CONTINUE READING

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