Significance of polyploidy in megakaryocytes and other cells in health and tumor disease

@article{Winkelmann2005SignificanceOP,
  title={Significance of polyploidy in megakaryocytes and other cells in health and tumor disease},
  author={M. Winkelmann and Peter Pfitzer and Wolfgang Schneider},
  journal={Klinische Wochenschrift},
  year={2005},
  volume={65},
  pages={1115-1131}
}
SummaryPolyploidy — the doubling of chromosome sets of cells caused by a stop of mitosis at different levels of the mitotic cycle — is a phenomenon widely observed in plants, protozoa, metazoa, and animals. In man obligate polyploid tissues are found in liver parenchyma, heart muscle cells, and bone marrow megakaryocytes. Polyploidy occurs mostly in stable and highly differentiated cells and tissues. Besides age, stimulation of proliferation and increased metabolic function lead to… 
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