Significance of polyploidy in megakaryocytes and other cells in health and tumor disease

@article{Winkelmann2005SignificanceOP,
  title={Significance of polyploidy in megakaryocytes and other cells in health and tumor disease},
  author={M. Winkelmann and P. Pfitzer and W. Schneider},
  journal={Klinische Wochenschrift},
  year={2005},
  volume={65},
  pages={1115-1131}
}
  • M. Winkelmann, P. Pfitzer, W. Schneider
  • Published 2005
  • Biology, Medicine
  • Klinische Wochenschrift
  • SummaryPolyploidy — the doubling of chromosome sets of cells caused by a stop of mitosis at different levels of the mitotic cycle — is a phenomenon widely observed in plants, protozoa, metazoa, and animals. In man obligate polyploid tissues are found in liver parenchyma, heart muscle cells, and bone marrow megakaryocytes. Polyploidy occurs mostly in stable and highly differentiated cells and tissues. Besides age, stimulation of proliferation and increased metabolic function lead to… CONTINUE READING
    Hepatocytes Polyploidization and Cell Cycle Control in Liver Physiopathology
    • 66
    • PDF
    The causes and consequences of polyploidy in normal development and cancer.
    • 299
    • PDF
    The origins and functions of hepatic polyploidy
    • 2
    Polyploidy in Animal Development and Disease
    Nuclear DNA Content Varies with Cell Size across Human Cell Types.
    • 33
    • PDF