Significance of plasma nitric oxide/endothelial-1 ratio for prediction of coronary artery disease.

@article{Kurita2005SignificanceOP,
  title={Significance of plasma nitric oxide/endothelial-1 ratio for prediction of coronary artery disease.},
  author={Akira Kurita and Takemi Matsui and Toshiaki Ishizuka and Bonpei Takase and Kimio Satomura},
  journal={Angiology},
  year={2005},
  volume={56 3},
  pages={259-64}
}
Vascular tone is regulated by vasodilators and vasoconstrictors. Endothelin-1 (ET-1) is the predominant vasoconstrictor peptide that constricts vascular smooth muscle, whereas nitric oxide (NO) is the primary vasodilator peptide that relaxes vascular smooth muscle. In this study, the authors examined whether NO/ET-1 ratio is a useful marker for detecting coronary artery disease (CAD), by comparison with evaluation based on vascular endothelial (VE) function. They measured plasma NOX and ET-1 by… CONTINUE READING